发明授权
- 专利标题： Aminopyrimidines as Syk inhibitors
- 专利标题（中）： 氨基嘧啶作为Syk抑制剂
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申请号： US14116207申请日： 2012-05-04
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公开(公告)号： US09290490B2公开(公告)日： 2016-03-22
- 发明人: Michael D. Altman , Kaleen Konrad Childers , Maria Emilia Di Francesco , John Michael Ellis , Christian Fischer , Jonathan Grimm , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Ryan D. Otte , Alessia Petrocchi , Adam J. Schell , Hua Zhou
- 申请人： Michael D. Altman , Kaleen Konrad Childers , Maria Emilia Di Francesco , John Michael Ellis , Christian Fischer , Jonathan Grimm , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Ryan D. Otte , Alessia Petrocchi , Adam J. Schell , Hua Zhou
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Eric A. Meade; Catherine D. Fitch
- 国际申请： PCT/US2012/036423 WO 20120504
- 国际公布： WO2012/154519 WO 20121115
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; A61K31/506 ; C07D487/04 ; C07D401/14 ; C07D417/12 ; C07D417/14
摘要：
The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.
公开/授权文献
- US20140148474A1 AMINOPYRIMIDINES AS SYK INHIBITORS 公开/授权日：2014-05-29
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