发明授权
US09267153B2 Porcine knob xenotype chimeric adenoviral vector for dendritic cell infection
有权
猪旋钮异种嵌合腺病毒载体树突状细胞感染
- 专利标题: Porcine knob xenotype chimeric adenoviral vector for dendritic cell infection
- 专利标题(中): 猪旋钮异种嵌合腺病毒载体树突状细胞感染
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申请号: US14365957申请日: 2012-12-14
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公开(公告)号: US09267153B2公开(公告)日: 2016-02-23
- 发明人: David T Curiel
- 申请人: Washington University
- 申请人地址: US MO Saint Louis
- 专利权人: Washington University
- 当前专利权人: Washington University
- 当前专利权人地址: US MO Saint Louis
- 代理机构: Zackson Law, LLC
- 代理商 Saul L. Zackson
- 国际申请: PCT/US2012/069884 WO 20121214
- 国际公布: WO2013/090806 WO 20130620
- 主分类号: C12N15/86
- IPC分类号: C12N15/86 ; A61K39/00
摘要:
Disclosed are methods of transforming dendritic cells with a chimeric adenovirus-5 (Ad5). A chimeric adenovirus includes a fiber comprising a tail, a shaft and a knob, wherein the knob is a porcine knob, and a nucleic acid comprising a promoter operably linked to a heterologous sequence encoding an antigen peptide.
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