Interface systems and methods are provided. An interface system can include a first isolator (200) and a second isolator (300) coupled to a modular interface (110). The interface can include a plurality of conductors (120). The first isolator can be coupled to a first signal format compliant first input/output (I/O) device (130). The second isolator can be coupled to a second signal format compliant second I/O device (140). The first isolator can pass a first signal format compliant signal to, and suppress the reflection of at least a portion of a second signal format compliant signal from, the first I/O device. The second isolator can at least partially block a first signal format compliant signal from, and to pass a second signal format compliant signal to, the second I/O device.