Invention Grant
- Patent Title: Method for determining ploidy of a cell
- Patent Title (中): 确定细胞倍性的方法
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Application No.: US13894886Application Date: 2013-05-15
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Publication No.: US09193992B2Publication Date: 2015-11-24
- Inventor: Bo U. Curry , Jayati Ghosh , Brian Jon Peter , Arjun Vadapalli
- Applicant: Agilent Technologies, Inc.
- Applicant Address: US CA Santa Clara
- Assignee: Agilent Technologies, Inc.
- Current Assignee: Agilent Technologies, Inc.
- Current Assignee Address: US CA Santa Clara
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/00 ; G06F19/18

Abstract:
A method for determining the ploidy of a test genome is provided. In some embodiments, the method may comprises: a) obtaining a plurality of ratios for polymorphisms that are distributed throughout a test genome, wherein each of the ratios is a ratio of the measured copy number of uncut allele in a polymorphic site relative to the measured copy number of the uncut allele in the reference sample; b) taking the log of the ratios and plotting a distribution of the reference corrected log ratios of the SNP probes; and c) determining the ploidy of said the genome based on the number of peaks in that distribution.
Public/Granted literature
- US20130323730A1 METHOD FOR DETERMINING PLOIDY OF A CELL Public/Granted day:2013-12-05
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