发明授权
US09163239B2 Compositions and methods for modulating apolipoprotein C-III expression
有权
调节载脂蛋白C-III表达的组合物和方法
- 专利标题： Compositions and methods for modulating apolipoprotein C-III expression
- 专利标题（中）： 调节载脂蛋白C-III表达的组合物和方法
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申请号： US14586826申请日： 2014-12-30
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公开(公告)号： US09163239B2公开(公告)日： 2015-10-20
- 发明人: Thazha P. Prakash , Punit P. Seth , Eric E. Swayze , Mark J. Graham
- 申请人： Isis Pharmaceuticals, Inc.
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Grant IP, Inc.
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04 ; C12N15/13 ; C12N15/113 ; C12N15/11
摘要：
Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein C-III (ApoCIII). In certain embodiments, the ApoCIII targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting ApoCIII for use in decreasing ApoCIII to treat, prevent, or ameliorate diseases, disorders or conditions related to ApoCIII. Certain diseases, disorders or conditions related to ApoCIII include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.
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