发明授权
US09162972B2 Method for production of hydroxycarboxylic acid amide compounds and novel arylboronic acid compound
有权
羟基羧酸酰胺化合物和新型芳基硼酸化合物的制备方法
- 专利标题: Method for production of hydroxycarboxylic acid amide compounds and novel arylboronic acid compound
- 专利标题(中): 羟基羧酸酰胺化合物和新型芳基硼酸化合物的制备方法
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申请号: US14377972申请日: 2013-02-14
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公开(公告)号: US09162972B2公开(公告)日: 2015-10-20
- 发明人: Kazuaki Ishihara , Akira Sakakura
- 申请人: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
- 申请人地址: JP Nagoya
- 专利权人: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
- 当前专利权人: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
- 当前专利权人地址: JP Nagoya
- 代理机构: Oliff PLC
- 优先权: JP2012-032400 20120217
- 国际申请: PCT/JP2013/053500 WO 20130214
- 国际公布: WO2013/122130 WO 20130822
- 主分类号: C07D211/18
- IPC分类号: C07D211/18 ; C07F5/02 ; C07C231/02 ; C07D211/16 ; B01J31/14 ; B01J31/02 ; C07B43/06
摘要:
A method for production of hydroxycarboxylic acid amide compounds, including performing amide condensation between an α- or β-hydroxycarboxylic acid compound and an amine compound in the presence as a catalyst of an alkylboronic acid represented by R3B(OH)2 (wherein R3 is a primary alkyl group) or an arylboronic acid compound to produce a hydroxycarboxylic acid amide compound, the arylboronic acid compound being represented by Formula (1): (in Formula (1), —(CH2)nNR1R2 is bonded at an ortho position or a para position, n is 1 or 2, R1 is a tertiary alkyl group, R2 is a secondary or tertiary alkyl group, and —NR1R2 may be a ring).
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