发明授权
- 专利标题： Isolation and use of melanoma cancer stem cells
- 专利标题（中）： 分离和使用黑色素瘤癌细胞
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申请号： US13498876申请日： 2010-09-29
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公开(公告)号： US09151760B2公开(公告)日： 2015-10-06
- 发明人: Irving L. Weissman , Alexander D. Boiko
- 申请人： Irving L. Weissman , Alexander D. Boiko
- 申请人地址： US CA Stanford
- 专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址： US CA Stanford
- 代理机构： Bozicevic, Field & Francis LLP
- 代理商 Pamela J. Sherwood
- 国际申请： PCT/US2010/050776 WO 20100929
- 国际公布： WO2011/041453 WO 20110407
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P35/00 ; A61K38/02 ; G01N33/574 ; C12N5/095 ; A61K47/48
摘要：
A set of markers for melanoma cancer stem cells are provided. The cells can be prospectively isolated or identified from primary tumor samples, and possess the unique properties of cancer stem cells in functional assays for tumor initiation, cancer stem cell self-renewal and differentiation. In addition, cancer stem cells can be used as a predictor for disease progression. The CSC have the phenotype of being positive for expression CD271.
公开/授权文献
- US20120225073A1 Isolation and Use of Melanoma Cancer Stem Cells 公开/授权日：2012-09-06
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