A system and method for efficiently handling misaligned memory accesses within a processor. A processor comprises a load-store unit (LSU) with a banked data cache (d-cache) and a banked store queue. The processor generates a first address corresponding to a memory access instruction identifying a first cache line. The processor determines the memory access is misaligned which crosses over a cache line boundary. The processor generates a second address identifying a second cache line logically adjacent to the first cache line. If the instruction is a load instruction, the LSU simultaneously accesses the d-cache and store queue with the first and the second addresses. If there are two hits, the data from the two cache lines are simultaneously read out. If the access is a store instruction, the LSU separates associated write data into two subsets and simultaneously stores these subsets in separate cache lines in separate banks of the store queue.