A method and apparatus for processing an ultrasound image are provided. The method includes determining similarities between a first two-dimensional (2D) ultrasound image, among 2D ultrasound images of a three-dimensional (3D) ultrasound image, and the 2D ultrasound images. The method further includes generating a predetermined number of similar ultrasound images with respect to the first 2D ultrasound image based on the similarities. The method further includes generating 3D volume data based on the predetermined number of the similar ultrasound images. The method further includes removing noise from the 3D volume data. The method further includes generating another 3D ultrasound image based on the noise-removed 3D volume data.