Invention Grant
- Patent Title: Neprilysin inhibitors
- Patent Title (中): Neprilysin抑制剂
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Application No.: US13961269Application Date: 2013-08-07
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Publication No.: US09126956B2Publication Date: 2015-09-08
- Inventor: Melissa Fleury , Adam D. Hughes
- Applicant: Melissa Fleury , Adam D. Hughes
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah
- Main IPC: A61K31/4192
- IPC: A61K31/4192 ; A61K45/06 ; C07D263/38 ; C07D231/14 ; C07D231/20 ; C07D405/12 ; C07D261/18 ; A61K31/415 ; A61K31/42 ; A61K31/421 ; C07D249/04

Abstract:
In one aspect, the invention relates to compounds having the formula: where X, Ra, Rb, R2, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
Public/Granted literature
- US20140045906A1 NEPRILYSIN INHIBITORS Public/Granted day:2014-02-13
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