In some embodiments, a serial bus interface circuit includes at least two serial ports, a memory to store a relationship between serial bus addresses and the at least two serial ports, and a controller to control access to the at least two serial ports. The controller may be configured to receive an access request for a serial bus address, determine a first port of the at least two serial ports corresponding to the serial bus address using the relationships stored in the memory, and disable a second port of the at least two serial ports. Other embodiments are disclosed and claimed.