Interference that occurs during wireless communication may be managed by determination and application of an adaptive path loss adjustment. A method, apparatus and medium of communication determine a level of excess received interference based at least in part on out-of-cell interference (Ioc). The path loss is adjusted by an additional path loss on an uplink signal when the level of excess received interference exceeds an interference target that would cause a Rise-over-Thermal (RoT) metric to exceed stable communication.