Methods for signaling multi-user multiple-input multiple output (MU-MIMO) parameters for Evolved-UTRA (E-UTRA) are disclosed. Example signaling format methods are presented that allow use of distributed virtual resource blocks (DVRB) or support of four wireless transmit/receive units (WTRUs) but maintaining a predetermined signal format size. A signaling format is also presented that signals transmission precoding matrix indexes used by all co-scheduled WTRUs.