Invention Grant
- Patent Title: N-carboxyalkyl-auristatin and the use thereof
- Patent Title (中): N-羧基烷基 - 阿司他丁及其用途
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Application No.: US13876777Application Date: 2011-09-26
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Publication No.: US08987209B2Publication Date: 2015-03-24
- Inventor: Hans-Georg Lerchen , Sherif El Sheikh , Beatrix Stelte-Ludwig , Sven Golfier , Joachim Schuhmacher , Jean Mark Gnoth , Ursula Krenz
- Applicant: Hans-Georg Lerchen , Sherif El Sheikh , Beatrix Stelte-Ludwig , Sven Golfier , Joachim Schuhmacher , Jean Mark Gnoth , Ursula Krenz
- Applicant Address: US WA Bothell
- Assignee: Seattle Genetics, Inc.
- Current Assignee: Seattle Genetics, Inc.
- Current Assignee Address: US WA Bothell
- Agency: Buchanan Ingersoll & Rooney PC
- Priority: EP10181966 20100929; EP11158466 20110316
- International Application: PCT/EP2011/066658 WO 20110926
- International Announcement: WO2012/041805 WO 20120405
- Main IPC: C07K5/00
- IPC: C07K5/00 ; C07K7/02 ; A61K38/08 ; C07K1/107 ; C07K5/02 ; A61K38/07 ; A61K45/06 ; A61K38/00
Abstract:
The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of diseases, particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments can occur as monotherapies or in combination with other medication or further therapeutic measures.
Public/Granted literature
- US20130261064A1 N-CARBOXYALKYL-AURISTATIN AND THE USE THEREOF Public/Granted day:2013-10-03
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