Aspects of a method and system for estimating and compensating for non-linear distortion in a transmitter using calibration are presented. Aspects of the system may include one more circuits that may enable estimation, within a single IC device, of distortion in output signals generated by a transmitter circuit. The circuitry may enable compensation of the estimated distortion by predistorting subsequent input signals. The transmitter circuit may generate subsequent output signals based on the predistorted subsequent input signals.