Systems and methods for application and network-based long poll request detection and cacheability assessment therefore are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a distributed proxy and cache system, including, determining relative timings between a first request initiated by the application, a response received responsive to the first request, and a second request initiated subsequent to the first request also by the application. The relative timings can be compared to request-response timing characteristics for other applications to determine whether the requests of the application are long poll requests.