Invention Grant
US08962853B2 Chemical probe compounds that become fluorescent upon reduction, and methods for their use
有权
在还原时变成荧光的化学探针化合物及其使用方法
- Patent Title: Chemical probe compounds that become fluorescent upon reduction, and methods for their use
- Patent Title (中): 在还原时变成荧光的化学探针化合物及其使用方法
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Application No.: US13975675Application Date: 2013-08-26
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Publication No.: US08962853B2Publication Date: 2015-02-24
- Inventor: Ching-Ying Cheung , Diane Gray , Stephen Yue
- Applicant: Life Technologies Corporation
- Applicant Address: US CA Carlsbad
- Assignee: Life Technologies Corporation
- Current Assignee: Life Technologies Corporation
- Current Assignee Address: US CA Carlsbad
- Agency: Life Technologies Corporation
- Main IPC: C07D291/00
- IPC: C07D291/00 ; C07C211/00 ; G01N33/58 ; C07D211/62 ; C07D295/112 ; C07D417/06 ; C07D417/14 ; C09B23/04 ; C12Q1/04 ; C12Q1/18 ; G01N33/52
Abstract:
Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents.
Public/Granted literature
- US20140127679A1 Chemical probe compounds that become fluorescent upon reduction, and methods for their use Public/Granted day:2014-05-08
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