发明授权
US08962671B2 Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
有权
氨基取代的3-杂芳酰基氨基 - 丙酸衍生物及其作为药物的用途
- 专利标题： Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
- 专利标题（中）： 氨基取代的3-杂芳酰基氨基 - 丙酸衍生物及其作为药物的用途
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申请号： US13357236申请日： 2012-01-24
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公开(公告)号： US08962671B2公开(公告)日： 2015-02-24
- 发明人: Sven Ruf , Thorsten Sadowski , Georg Horstick , Herman Schreuder , Christian Buning , Thomas Olpp , Klaus Wirth
- 申请人： Sven Ruf , Thorsten Sadowski , Georg Horstick , Herman Schreuder , Christian Buning , Thomas Olpp , Klaus Wirth
- 申请人地址： FR Paris
- 专利权人： Sanofi
- 当前专利权人： Sanofi
- 当前专利权人地址： FR Paris
- 代理机构： Scully, Scott, Murphy & Presser P.C.
- 优先权： EP11305077 20110126
- 主分类号： A61K31/4155
- IPC分类号： A61K31/4155 ; C07D231/38 ; C07D275/02 ; C07D401/12 ; C07D403/04 ; C07D401/04 ; C07D403/06 ; C07D405/12 ; C07D417/04 ; C07D487/04
摘要：
The present invention relates to compounds of the formula I, wherein A, D, E, G, R10, R11, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
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