发明授权
- 专利标题： Macrocycles as factor XIa inhibitors
- 专利标题（中）： 大环作为因子XIa抑制剂
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申请号： US13024544申请日： 2011-02-10
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公开(公告)号： US08940720B2公开(公告)日： 2015-01-27
- 发明人: James R. Corte , Tianan Fang , Carl P. Decicco , Donald J. P. Pinto , Karen A. Rossi , Zilun Hu , Yoon Jeon , Mimi L. Quan , Joanne M. Smallheer , Yufeng Wang , Wu Yang
- 申请人： James R. Corte , Tianan Fang , Carl P. Decicco , Donald J. P. Pinto , Karen A. Rossi , Zilun Hu , Yoon Jeon , Mimi L. Quan , Joanne M. Smallheer , Yufeng Wang , Wu Yang
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Hong Liu
- 主分类号： C07D487/08
- IPC分类号： C07D487/08 ; C07D487/02 ; A61K31/33 ; A61K31/395 ; C07D498/08
摘要：
The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
公开/授权文献
- US20120041190A1 MACROCYCLES AS FACTOR XIA INHIBITORS 公开/授权日：2012-02-16
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