发明授权
- 专利标题： Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists
- 专利标题（中）： 内皮素，内皮素激动剂和肾上腺髓质素拮抗剂危重病人诊断和治疗方法
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申请号： US12364911申请日： 2009-02-03
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公开(公告)号： US08906857B2公开(公告)日： 2014-12-09
- 发明人: Andreas Bergmann , Joachim Struck , Nils G. Morgenthaler
- 申请人： Andreas Bergmann , Joachim Struck , Nils G. Morgenthaler
- 申请人地址： DE Hennigsdorf
- 专利权人： B.R.A.H.M.S. GmbH
- 当前专利权人： B.R.A.H.M.S. GmbH
- 当前专利权人地址： DE Hennigsdorf
- 代理机构： Millen, White, Zelano, Branigan, P.C.
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; G01N33/53 ; A61K38/17 ; G01N33/74 ; C07K16/22 ; C07K16/26
摘要：
The ratio of concentrations of pro-adrenomedullin (pro-ADM)/pro-endothelin (pro-END) immunoreactivity in body fluids of critically ill patients is used as for the diagnosis, course control and prognosis, including an assessment of the mortality risk, of severe life threatening diseases. Further, a treatment of critically ill patients having high levels of pro-ADM but insufficient levels of pro-END immunoreactivities with a medicament comprising vasoconstrictive endothelin or its precursors, and/or endothelin agonists or adrenomedullin antagonists is provided.
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