A method of transmitting a sounding reference signal (SRS) includes receiving SRS operation information including a sounding indicator, the sounding indicator indicating whether SRS transmission takes place at a subframe; generating the SRS according to the SRS operation information, and if the sounding indicator indicates occurrence of SRS transmission, transmitting the SRS at the subframe. Multiplexing can be achieved without collision between data and a sounding reference signal and single carrier characteristics required in uplink transmission can be preserved.