发明授权
US08883476B2 Mutant of propionyl-CoA transferase from Clostridium propionicum and preparing method for PLA or PLA copolymer using the same
有权
丙酸酰辅酶A转移酶由丙酸梭菌的突变体及使用其的PLA或PLA共聚物的制备方法
- 专利标题： Mutant of propionyl-CoA transferase from Clostridium propionicum and preparing method for PLA or PLA copolymer using the same
- 专利标题（中）： 丙酸酰辅酶A转移酶由丙酸梭菌的突变体及使用其的PLA或PLA共聚物的制备方法
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申请号： US13952355申请日： 2013-07-26
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公开(公告)号： US08883476B2公开(公告)日： 2014-11-11
- 发明人: Si Jae Park , Taek Ho Yang , Hye Ok Kang , Sang Hyun Lee , Eun Jung Lee , Tae Wan Kim
- 申请人： Si Jae Park , Taek Ho Yang , Hye Ok Kang , Sang Hyun Lee , Eun Jung Lee , Tae Wan Kim
- 申请人地址： KR Seoul
- 专利权人： LG Chem, Ltd.
- 当前专利权人： LG Chem, Ltd.
- 当前专利权人地址： KR Seoul
- 代理机构： McKenna Long & Aldridge, LLP
- 优先权： KR10-2007-0081855 20070814
- 主分类号： C12N1/10
- IPC分类号： C12N1/10 ; C12P7/62 ; C07H21/04 ; C12N9/10
摘要：
Provided is a mutant of propionyl-CoA transferase from Clostridium propionicum that can convert lactate into lactyl-CoA with high efficiency in a method of preparing a polylactate (PLA) or PLA copolymer using microorganisms. Unlike conventional propionyl-CoA transferase which is weakly expressed in E. coli, when a mutant of propiony-CoA transferase from Clostridium propionicum is introduced into recombinant E. coli, lactyl-CoA can be supplied very smoothly, thereby enabling highly efficient preparation of polylactate (PLA) and PLA copolymer.
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