发明授权
- 专利标题： Modified SAK gene for the production of recombinant proteins
- 专利标题（中）： 修饰的SAK基因用于生产重组蛋白
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申请号： US13702028申请日： 2011-06-03
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公开(公告)号： US08853380B2公开(公告)日： 2014-10-07
- 发明人: Shardul Salunkhe , Bhaskarjyoti Prasad , Praveen Muneshwar , Anjali Apte Deshpande , Sriram Padmanabhan
- 申请人： Shardul Salunkhe , Bhaskarjyoti Prasad , Praveen Muneshwar , Anjali Apte Deshpande , Sriram Padmanabhan
- 申请人地址： IN Mumbai, Maharashtra
- 专利权人： Lupin Limited
- 当前专利权人： Lupin Limited
- 当前专利权人地址： IN Mumbai, Maharashtra
- 代理机构： Merchant & Gould P.C.
- 优先权： IN607/KOL/2010 20100604
- 国际申请： PCT/IB2011/001210 WO 20110603
- 国际公布： WO2011/151714 WO 20111208
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12N9/00 ; C12P21/06 ; C07K14/555 ; C07K14/535 ; C07K14/54 ; C07K14/49 ; C07K14/55 ; C12N9/96 ; C07K14/635 ; C12N9/72 ; C07K14/31 ; C07K14/485
摘要：
The present invention relates to modified SAK gene having amino acid SEQ ID 2. The present invention further relates to process for cloning and expressing modified SAK gene fusion protein which imparts improved stability to the heterologous protein of interest. Further the invention relates to process of purification of recombinant heterologous proteins from bacterial inclusion bodies using modified SAK.
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