发明授权
US08853212B2 Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
有权
取代的氨基四氢硫代吡喃及其衍生物作为二肽基肽酶-IV抑制剂用于治疗糖尿病
- 专利标题： Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
- 专利标题（中）： 取代的氨基四氢硫代吡喃及其衍生物作为二肽基肽酶-IV抑制剂用于治疗糖尿病
-
申请号： US13520653申请日： 2011-02-17
-
公开(公告)号： US08853212B2公开(公告)日： 2014-10-07
- 发明人: Robert R. Wilkening , James M. Apgar , Tesfaye Biftu , Danqing Feng , Xiaoxia Qian , Lan Wei
- 申请人： Robert R. Wilkening , James M. Apgar , Tesfaye Biftu , Danqing Feng , Xiaoxia Qian , Lan Wei
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp
- 当前专利权人： Merck Sharp & Dohme Corp
- 当前专利权人地址： US NJ Rahway
- 代理商 Janet E. Fair; Anna L. Cocuzzo
- 国际申请： PCT/US2011/025182 WO 20110217
- 国际公布： WO2011/103256 WO 20110825
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D498/04 ; A61K31/519 ; A61K31/404 ; A61K31/4162 ; A61K31/4188 ; A61K31/424 ; A61K31/4985 ; A61P29/00 ; A61P37/00 ; A61P9/00 ; A61P3/10 ; C07D335/02
摘要：
The present invention is directed to novel substituted aminotetrahydrothiopyrans and derivatives thereof of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
公开/授权文献
信息查询
