发明授权
- 专利标题： Lithium stimulation of cord blood stem cell proliferation and growth factor production
- 专利标题（中）： 锂刺激脐血干细胞增殖和生长因子的产生
-
申请号： US12513331申请日： 2007-10-31
-
公开(公告)号： US08852938B2公开(公告)日： 2014-10-07
- 发明人: DongMing Sun , Wise Young
- 申请人： DongMing Sun , Wise Young
- 申请人地址： US NJ New Brunswick
- 专利权人： Rutgers, The State University of New Jersey
- 当前专利权人： Rutgers, The State University of New Jersey
- 当前专利权人地址： US NJ New Brunswick
- 代理机构： Kilpatrick Townsend & Stockton LLP
- 国际申请： PCT/US2007/083210 WO 20071031
- 国际公布： WO2008/055224 WO 20080508
- 主分类号： C12N5/02
- IPC分类号： C12N5/02 ; C12N5/0789 ; A61K35/50
摘要：
The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing the survival and growth of transplanted cord blood stem cells by treating the cells with a lithium salt prior to transplantation. In vivo methods for reducing rejection of transplanted cord blood stem cells by administering a lithium salt after transplantation are also provided.
公开/授权文献
信息查询
