An electronic device with a guiding mechanism for guiding a flexible printed circuit board includes a base, a cover, two guiding members, a pushing member, the flexible printed circuit board (FPC) and a rotating member. A through hole is formed on the base. The cover is movably disposed on a first side of the base. The two guiding members are disposed on the second side of the base in parallel. The pushing member is slidably disposed on the two guiding members and has a guiding surface. An end of the FPC is connected to the cover and an other end of the FPC passes through the through hole and surrounds the guiding surface of the pushing member so as to be connected to the base. The rotating member is rotatably disposed on the second side of the base and has a pushing portion abutting against the pushing member.