发明授权
- 专利标题： Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
- 专利标题（中）： 11β-羟基类固醇脱氢酶的循环抑制剂1
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申请号： US13347784申请日： 2012-01-11
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公开(公告)号： US08673899B2公开(公告)日： 2014-03-18
- 发明人: David A. Claremon , Linghang Zhuang , Katerina Leftheris , Colin M. Tice , Zhenrong Xu , Yuanjie Ye , Suresh B. Singh , Salvacion Cacatian , Wei Zhao
- 申请人： David A. Claremon , Linghang Zhuang , Katerina Leftheris , Colin M. Tice , Zhenrong Xu , Yuanjie Ye , Suresh B. Singh , Salvacion Cacatian , Wei Zhao
- 申请人地址： US PA Fort Washington DE
- 专利权人： Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International GmbH
- 当前专利权人： Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International GmbH
- 当前专利权人地址： US PA Fort Washington DE
- 代理机构： McCarter & English, LLP
- 代理商 Stephen G. Davis; Michael J. DeGrazia
- 优先权： WOPCT/US2008/009017 20080725
- 主分类号： C07D413/10
- IPC分类号： C07D413/10 ; C07D413/14 ; A61K31/5355
摘要：
This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
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