发明授权
US08648181B2 Methods and compositions of DNA ligands for arthropod-borne pathogen detection and prophylaxis or therapy
失效
用于节肢动物传播的病原体检测和预防或治疗的DNA配体的方法和组成
- 专利标题： Methods and compositions of DNA ligands for arthropod-borne pathogen detection and prophylaxis or therapy
- 专利标题（中）： 用于节肢动物传播的病原体检测和预防或治疗的DNA配体的方法和组成
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申请号： US13199082申请日： 2011-08-18
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公开(公告)号： US08648181B2公开(公告)日： 2014-02-11
- 发明人: John G. Bruno
- 申请人： John G. Bruno
- 申请人地址： US TX San Antonio
- 专利权人： OTC Biotechnologies, LLC
- 当前专利权人： OTC Biotechnologies, LLC
- 当前专利权人地址： US TX San Antonio
- 代理机构： Rosenthal Pauerstein Sandoloski Agather LLP
- 代理商 William H. Quirk; Daniel A. Rogers
- 主分类号： C07H21/04
- IPC分类号： C07H21/04
摘要：
Specific DNA ligand sequences for binding various arthropod-borne pathogens including arboviruses, rickettsia and parasites are described. Each of these sequences or their linear, two-and three-dimesional linked sequences can function in varying assay and sensor formats with varying degrees of success. Linkage of the whole or partial DNA sequences (putative binding sites) can be used to enhance specificity and affinity towards complex targets, thereby improving assay selectivity and sensitivity in many instances. In addition, the DNA sequences may bind and neutralize or prevent infection from arthropod-borne viruses, rickettsia and Leishmania or other parasites.
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