发明授权
- 专利标题： Artificial tissue constructs comprising alveolar cells and methods for using the same
- 专利标题（中）： 包含肺泡细胞的人造组织构建体及其使用方法
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申请号： US12173921申请日： 2008-07-16
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公开(公告)号： US08647837B2公开(公告)日： 2014-02-11
- 发明人: Ayesha Mahmood , Anatoly Kachurin , William Warren , Russell Higbee
- 申请人： Ayesha Mahmood , Anatoly Kachurin , William Warren , Russell Higbee
- 申请人地址： US FL Orlando
- 专利权人： Sanofi Pasteur Vaxdesign Corp.
- 当前专利权人： Sanofi Pasteur Vaxdesign Corp.
- 当前专利权人地址： US FL Orlando
- 代理机构： Roylance, Abrams, Berdo & Goodman LLP
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/53 ; C12Q1/02
摘要：
The present invention comprises artificial tissue constructs that serve as in vitro models of mammalian lung tissue. The artificial tissue constructs of the present invention comprise functionally equivalent in vitro tissue scaffolds that enable immunophysiological function of the lung. The constructs can serve as novel platforms for the study of lung diseases (e.g., interstitial lung diseases, fibrosis, influenza, RSV) as well as smoke- and smoking-related diseases. The artificial tissue constructs of the present invention comprise the two components of alveolar tissue, epithelial and endothelial cell layers.
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