The invention relates to a system and a method for analysis and evaluation of at least one anatomical structure in a medical image, said medical image representing at least a part of a patient or person, said system comprising image analyzing means for calculating the volume and/or providing the shape of the at least one anatomical structure, and statistical analyzing means for providing a confidence interval of the volume and/or the shape of the analyzed anatomical structure(s) based on individual data of the patient or person, thereby quantifying the normality of said anatomical structure(s). By the present system and method a detailed and trustworthy confidence interval can be provided in connection with analysis and evaluation of a medical image of a patient, thereby illustrating the expected normality of the patient. The invention can be applied to images acquired from magnetic resonance imaging (MRI). One example of use is for diagnosing diseases and/or initial stages of diseases.