发明授权
US08632995B2 High-cell density fed-batch fermentation process for producing recombinant protein
有权
用于生产重组蛋白的高细胞密度补料分批发酵方法
- 专利标题： High-cell density fed-batch fermentation process for producing recombinant protein
- 专利标题（中）： 用于生产重组蛋白的高细胞密度补料分批发酵方法
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申请号： US11829703申请日： 2007-07-27
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公开(公告)号： US08632995B2公开(公告)日： 2014-01-21
- 发明人: Wei-Qiang Willie Sun , Earl Pursell
- 申请人： Wei-Qiang Willie Sun , Earl Pursell
- 申请人地址： US NJ Madison
- 专利权人： Wyeth LLC
- 当前专利权人： Wyeth LLC
- 当前专利权人地址： US NJ Madison
- 代理商 Anna C. Chau
- 主分类号： C12P21/06
- IPC分类号： C12P21/06
摘要：
Methods for producing proteins, for example, recombinant meningococcal 2086 proteins, using fed-batch fermentation with continuous input of an inducer after achieving a threshold parameter, and optionally continuous input of a carbon source, for example, a constant rate input, to improve protein yields, as well as high density protein compositions and compositions for use in the methods of the present invention, are provided.
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