发明授权
- 专利标题: Microcrystalline cellulose and calcium carbonate compositions useful as recompactible pharmaceutical excipients
- 专利标题(中): 可用作可再生药物赋形剂的微晶纤维素和碳酸钙组合物
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申请号: US12962992申请日: 2010-12-08
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公开(公告)号: US08632819B2公开(公告)日: 2014-01-21
- 发明人: Gregory Thoorens , Bruno LeClercq , Thomas Ruszkay
- 申请人: Gregory Thoorens , Bruno LeClercq , Thomas Ruszkay
- 申请人地址: US PA Philadelphia
- 专利权人: FMC Corporation
- 当前专利权人: FMC Corporation
- 当前专利权人地址: US PA Philadelphia
- 代理机构: FMC Corporation
- 主分类号: A61K9/16
- IPC分类号: A61K9/16 ; A61K9/20 ; A61K47/38 ; G01N3/08
摘要:
Coprocessed compositions containing microcrystalline cellulose and calcium carbonate, wherein the weight ratio of microcrystalline cellulose to calcium carbonate is relatively high, are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. Such compositions may be obtained, for example, by preparing aqueous slurries or wet masses of microcrystalline cellulose and calcium carbonate and drying such slurries or wet masses to produce particulate products. The coprocessed products exhibit improved recompactibility, as compared to coprocessed products having lower microcrystalline cellulose:calcium carbonate weight ratios or as compared to physical dry blends of the two excipients.
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