发明授权
US08632819B2 Microcrystalline cellulose and calcium carbonate compositions useful as recompactible pharmaceutical excipients 有权
可用作可再生药物赋形剂的微晶纤维素和碳酸钙组合物

Microcrystalline cellulose and calcium carbonate compositions useful as recompactible pharmaceutical excipients
摘要:
Coprocessed compositions containing microcrystalline cellulose and calcium carbonate, wherein the weight ratio of microcrystalline cellulose to calcium carbonate is relatively high, are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. Such compositions may be obtained, for example, by preparing aqueous slurries or wet masses of microcrystalline cellulose and calcium carbonate and drying such slurries or wet masses to produce particulate products. The coprocessed products exhibit improved recompactibility, as compared to coprocessed products having lower microcrystalline cellulose:calcium carbonate weight ratios or as compared to physical dry blends of the two excipients.
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