发明授权
US08540987B2 Composition for neutralizing botulinus toxin type-A, and human anti-botulinus toxin type-A antibody
有权
用于中和A型肉毒杆菌毒素和A型抗人类肉毒毒素毒素的组合物
- 专利标题： Composition for neutralizing botulinus toxin type-A, and human anti-botulinus toxin type-A antibody
- 专利标题（中）： 用于中和A型肉毒杆菌毒素和A型抗人类肉毒毒素毒素的组合物
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申请号： US12864018申请日： 2009-01-23
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公开(公告)号： US08540987B2公开(公告)日： 2013-09-24
- 发明人: Masachika Azuma , Motohide Takahashi , Shunji Kozaki , Masafumi Mukamoto , Tomoko Kohda , Gene Kurosawa , Yoshikazu Kurosawa
- 申请人： Masachika Azuma , Motohide Takahashi , Shunji Kozaki , Masafumi Mukamoto , Tomoko Kohda , Gene Kurosawa , Yoshikazu Kurosawa
- 申请人地址： JP Nagoya-shi JP Tokyo JP Sakai-shi
- 专利权人： Institute for Antibodies Co., Ltd.,Japan as Represented by Director-General of National Institute of Infectious Diseases,Osaka Prefecture University Public Corporation
- 当前专利权人： Institute for Antibodies Co., Ltd.,Japan as Represented by Director-General of National Institute of Infectious Diseases,Osaka Prefecture University Public Corporation
- 当前专利权人地址： JP Nagoya-shi JP Tokyo JP Sakai-shi
- 代理机构： Edwards Wildman Palmer LLP
- 代理商 James E. Armstrong, IV; Edmund J. Koundakjian
- 优先权： JP2008-017152 20080129
- 国际申请： PCT/JP2009/000250 WO 20090123
- 国际公布： WO2009/096162 WO 20090806
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K39/00 ; C07K16/00 ; C12P21/08
摘要：
Provided herein is a means which is effective for botulism diseases and the prevention of the botulism diseases. Specifically provided is a plurality of human anti-botulinum toxin type-A antibodies having different epitopes from one another. Also specifically provided is a composition for neutralizing botulinum toxin type-A, which comprises a combination of two or more of the antibodies and which has a high neutralizing activity.
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