Systems and methods provide acceleration of automatic test pattern generation in a multi-core computing environment via multi-level parameter value optimization for a parameter set with speculative scheduling. The methods described herein use multi-core based parallel runs to parallelize sequential execution, speculative software execution to explore possible parameter sets, and terminate/prune runs when the optimum parameter value is found at a previous level. The present invention evaluates the design prior to the implementation of the compression IP so that it can define the configuration of DFT and ATPG to maximize the results of compression as measured by test data volume and test application time.