- 专利标题: Substituted benzamidines as antibacterial agents
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申请号: US12679334申请日: 2008-09-22
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公开(公告)号: US08415383B2公开(公告)日: 2013-04-09
- 发明人: David John Haydon , Ian Collins , Lloyd George Czaplewski
- 申请人: David John Haydon , Ian Collins , Lloyd George Czaplewski
- 申请人地址: AU Notting Hill, Victoria
- 专利权人: Biota Scientific Management Pty Ltd
- 当前专利权人: Biota Scientific Management Pty Ltd
- 当前专利权人地址: AU Notting Hill, Victoria
- 代理机构: Banner & Witcoff, Ltd.
- 优先权: GB0718735.4 20070925
- 国际申请: PCT/GB2008/003208 WO 20080922
- 国际公布: WO2009/040507 WO 20090402
- 主分类号: A01N43/40
- IPC分类号: A01N43/40 ; A61K31/44
摘要:
Compounds of formula (IA) or (IB) have antibacterial activity: wherein W is ═C(H)— or ═N—; R3 is a radical of formula -(Alk1)m-(Z1)p-(Alk2)n-Q wherein m, p and n are independently 0 or 1, provided that at least one of m, p and n is 1, Z1 is —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, —N(CH2CH3)—, —C(—O)—, —0—(C═O)—, —C(═O)—O—, or an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted divalent bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; Alk1 and Alk2 are optionally substituted C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radicals, which may optionally terminate with or be interrupted by —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, Or —N(CH2CH3)—; and Q is hydrogen, halogen, nitrile, or hydroxyl, or an optionally substituted monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; R4 and R5 are optional substituents; and R2, R6 and R7 are independently hydrogen or a radical of formula -(Alk3)x-(Z2)y-(Alk4)z-H wherein x, y and z are independently 0 or 1, Z2 is —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, —N(CH2CH3)—, —C(—O)—, —0—(C═O)— or —C(═O)—O—; Alk3 and Alk4 are optionally substituted C1-C3 alkylene, C2-C3 alkenylene, or C2-C3 alkynylene radicals, which may optionally terminate with or be interrupted by —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, or —N(CH2CH3)—.
公开/授权文献
- US20100298388A1 SUBSTITUTED BENAMIDINES AS ANTIBACTERIAL AGENTS 公开/授权日:2010-11-25
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