发明授权
US08370074B2 System and methods for predicting transmembrane domains in membrane proteins and mining the genome for recognizing G-protein coupled receptors
有权
用于预测膜蛋白中跨膜结构域的系统和方法，并开采用于识别G蛋白偶联受体的基因组
- 专利标题： System and methods for predicting transmembrane domains in membrane proteins and mining the genome for recognizing G-protein coupled receptors
- 专利标题（中）： 用于预测膜蛋白中跨膜结构域的系统和方法，并开采用于识别G蛋白偶联受体的基因组
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申请号： US12606605申请日： 2009-10-27
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公开(公告)号： US08370074B2公开(公告)日： 2013-02-05
- 发明人: Rene J. Trabanino , Nagarajan Vaidehi , Spencer E. Hall , William A. Goddard , Wely Floriano
- 申请人： Rene J. Trabanino , Nagarajan Vaidehi , Spencer E. Hall , William A. Goddard , Wely Floriano
- 申请人地址： US CA Pasadena
- 专利权人： California Institute of Technology
- 当前专利权人： California Institute of Technology
- 当前专利权人地址： US CA Pasadena
- 代理机构： McCarter & English, LLP
- 代理商 Elizabeth A. Hanley; Yu Lu
- 主分类号： G01N33/48
- IPC分类号： G01N33/48 ; C12Q1/68 ; G06G7/58 ; G06F7/60
摘要：
The invention provides computer-implemented methods and apparatus implementing a hierarchical protocol using multiscale molecular dynamics and molecular modeling methods to predict the presence of transmembrane regions in proteins, such as G-Protein Coupled Receptors (GPCR), and protein structural models generated according to the protocol. The protocol features a coarse grain sampling method, such as hydrophobicity analysis, to provide a fast and accurate procedure for predicting transmembrane regions. Methods and apparatus of the invention are useful to screen protein or polynucleotide databases for encoded proteins with transmembrane regions, such as GPCRs.
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