Invention Grant
US08367710B2 Bicyclo-substituted pyrazolon azo derivatives, preparation process and pharmaceutical use thereof
有权
双环取代的吡唑啉偶氮衍生物，其制备方法和药物用途
- Patent Title: Bicyclo-substituted pyrazolon azo derivatives, preparation process and pharmaceutical use thereof
- Patent Title (中): 双环取代的吡唑啉偶氮衍生物，其制备方法和药物用途
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Application No.: US12812119Application Date: 2009-01-04
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Publication No.: US08367710B2Publication Date: 2013-02-05
- Inventor: Peng Cho Tang , Hejun Lü , Hao Zheng , Yiqian Chen , Hongbo Fei , Shenglan Wang , Li Wang
- Applicant: Peng Cho Tang , Hejun Lü , Hao Zheng , Yiqian Chen , Hongbo Fei , Shenglan Wang , Li Wang
- Applicant Address: CN Jiangsu CN Shanghai
- Assignee: Jiangsu Hengrui Medicine Co. Ltd.,Shanghai Hengrui Pharmaceutical Co. Ltd.
- Current Assignee: Jiangsu Hengrui Medicine Co. Ltd.,Shanghai Hengrui Pharmaceutical Co. Ltd.
- Current Assignee Address: CN Jiangsu CN Shanghai
- Agency: Brinks Hofer Gilson & Lione
- Agent Ryan L. Marshall
- Priority: CN200810000346 20080110
- International Application: PCT/CN2009/000001 WO 20090104
- International Announcement: WO2009/092276 WO 20090730
- Main IPC: A61K31/4196
- IPC: A61K31/4196 ; A61K31/41 ; A61K38/20 ; C07D231/46 ; C07D403/12 ; C07D405/10 ; C07D231/26 ; A61P7/00
Abstract:
The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor are disclosed. The definition of substituents in formula (I) are the same as defined in the description.
Public/Granted literature
- US20100316601A1 BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF Public/Granted day:2010-12-16
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