An iterative reception method and iterative receiver in a mobile communication system are provided. In order to remove inter-cell interference of a signal that is iteratively received in a multi-cell environment, a soft determination value of different cells excluding a specific cell is re-spread to be used. In addition, in order to improve reception performance of the iterative receiver that performs the interference removal by using the soft determination value, channel estimation is iteratively performed on the iteratively received signal by using a soft determination value of a previous order of the specific cell to update a channel estimation value. Accordingly, it is possible to reduce complexity of implementation and effectively remove the inter-cell interference by using the soft determination value.