发明授权
- 专利标题： HGF precursor protein variant and active protein thereof
- 专利标题（中）： HGF前体蛋白质变体及其活性蛋白质
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申请号： US13175110申请日： 2011-07-01
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公开(公告)号： US08278270B2公开(公告)日： 2012-10-02
- 发明人: Toshikazu Nakamura , Kunio Matsumoto , Kazuhiro Fukuta , Kiichi Adachi , Daichika Hayata
- 申请人： Toshikazu Nakamura , Kunio Matsumoto , Kazuhiro Fukuta , Kiichi Adachi , Daichika Hayata
- 申请人地址： JP Osaka JP Osaka
- 专利权人： Kringle Pharma Inc.,Osaka University
- 当前专利权人： Kringle Pharma Inc.,Osaka University
- 当前专利权人地址： JP Osaka JP Osaka
- 代理机构： Wenderoth, Lind & Ponack, L.L.P.
- 优先权： JP2006-116498 20060420
- 主分类号： A61K38/18
- IPC分类号： A61K38/18 ; C12P21/04 ; C12P21/06 ; C12N15/00 ; C12N5/00 ; C07K14/475
摘要：
An HGF precursor protein variant, in which a peptide structure comprises a sequence including a peptide chain X inserted between an α chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the C-terminus of the α chain are deleted, and a β chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the N-terminus of the β chain are deleted; wherein (i) the peptide chain X has an amino-acid sequence of at least two residues, (ii) the peptide chain X can be cleaved by a protease reaction or a chemical reaction, and (iii) a protein obtained by cleaving at least one site of the peptide chain X has HGF action.
公开/授权文献
- US20110269944A1 HGF PRECURSOR PROTEIN VARIANT AND ACTIVE PROTEIN THEREOF 公开/授权日：2011-11-03
信息查询
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