发明授权
US08273891B2 Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
失效
吲唑类，苯并噻唑类，苯并异噻唑类，苯并异恶唑类，吡唑并吡啶类，异噻唑啉类及其制备方法
- 专利标题： Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
- 专利标题（中）： 吲唑类，苯并噻唑类，苯并异噻唑类，苯并异恶唑类，吡唑并吡啶类，异噻唑啉类及其制备方法
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申请号： US12700936申请日： 2010-02-05
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公开(公告)号： US08273891B2公开(公告)日： 2012-09-25
- 发明人: Richard Schumacher , Mihaela Diana Danca , Jianguo Ma , Brian Herbert , True Minh Nguyen , Wenge Xie , Ashok Tehim
- 申请人： Richard Schumacher , Mihaela Diana Danca , Jianguo Ma , Brian Herbert , True Minh Nguyen , Wenge Xie , Ashok Tehim
- 申请人地址： US NJ Montvale
- 专利权人： Memory Pharmaceuticals Corporation
- 当前专利权人： Memory Pharmaceuticals Corporation
- 当前专利权人地址： US NJ Montvale
- 代理机构： Millen, White, Zelano & Branigan, P.C.
- 主分类号： C07D221/02
- IPC分类号： C07D221/02 ; C07D217/00
摘要：
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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