发明授权
- 专利标题： Process for preparing benzazepine compounds or salts thereof
- 专利标题（中）： 制备苯并氮杂化合物或其盐的方法
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申请号： US12064178申请日： 2006-09-01
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公开(公告)号： US08273735B2公开(公告)日： 2012-09-25
- 发明人: Yasuhiro Torisawa , Kaoru Abe , Yasuaki Muguruma , Shigekazu Fujita , Hidenori Ogawa , Naoto Utsumi , Masahiro Miyake
- 申请人： Yasuhiro Torisawa , Kaoru Abe , Yasuaki Muguruma , Shigekazu Fujita , Hidenori Ogawa , Naoto Utsumi , Masahiro Miyake
- 申请人地址： JP Tokyo
- 专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- 优先权： JP2005-254744 20050902
- 国际申请： PCT/JP2006/317804 WO 20060901
- 国际公布： WO2007/026971 WO 20070308
- 主分类号： C07D223/16
- IPC分类号： C07D223/16
摘要：
This invention provides a process for preparing benzazepine compounds of the formula (1): wherein X1 is a halogen atom, R1 and R2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.
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