发明授权
- 专利标题： Pyridazinone derivatives as PARP inhibitors
- 专利标题（中）： 哒嗪酮衍生物作为PARP抑制剂
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申请号： US12739262申请日： 2008-11-14
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公开(公告)号： US08268827B2公开(公告)日： 2012-09-18
- 发明人: Danila Branca , Gabriella Dessole , Federica Ferrigno , Philip Jones , Olaf Kinzel , Samuele Lillini , Ester Muraglia , Giovanna Pescatore , Carsten Schultz-Fademrecht
- 申请人： Danila Branca , Gabriella Dessole , Federica Ferrigno , Philip Jones , Olaf Kinzel , Samuele Lillini , Ester Muraglia , Giovanna Pescatore , Carsten Schultz-Fademrecht
- 申请人地址： IT Pomezia, Rome
- 专利权人： Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA.
- 当前专利权人： Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA.
- 当前专利权人地址： IT Pomezia, Rome
- 代理商 Yong Zhao; David A. Muthard; Matthew A. Leff
- 优先权： GB0722401.7 20071115; GB0816707.4 20080912
- 国际申请： PCT/GB2008/051063 WO 20081114
- 国际公布： WO2009/063244 WO 20090522
- 主分类号： C07D401/00
- IPC分类号： C07D401/00 ; A60K31/50
摘要：
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
公开/授权文献
- US20100261709A1 PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS 公开/授权日：2010-10-14
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