An axle arrangement (1) for two-wheelers, particularly for bicycles, includes a quick-release axle (2) having an axle (6) as the supporting part for a hub (7). The axle (6) can be inserted in receiving or dropout ends (3, 4) of a fork (5), a linkage, a rear end or similar mount. The axle (6) has a threaded end (16) and a quick-release fastener (9) with a tensioning lever (10) on the other end. One of the dropout ends (3, 4), or an intermediate supporting part that can be connected to the dropout ends (3, 4), has a screw-in thread (15) for screwing in the one threaded axle end (16) of the axle (6). In addition, an adjustable stop may be provided for the purpose of limiting the screw-in depth of the threaded axle end (16) in the screw-in thread (15) of the dropout ends or in the screw-in thread (15) of the intermediate supporting part connected to the dropout ends (3, 4).