发明授权
- 专利标题： Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
- 专利标题（中）： 11＆bgr-羟基类固醇脱氢酶的循环抑制剂1
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申请号： US12990309申请日： 2009-04-30
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公开(公告)号： US08242111B2公开(公告)日： 2012-08-14
- 发明人: David A. Claremon , Linghang Zhuang , Katerina Leftheris , Colin M. Tice , Yuanjie Ye , Suresh B. Singh
- 申请人： David A. Claremon , Linghang Zhuang , Katerina Leftheris , Colin M. Tice , Yuanjie Ye , Suresh B. Singh
- 申请人地址： US PA Fort Washington
- 专利权人： Vitae Pharmaceuticals, Inc.
- 当前专利权人： Vitae Pharmaceuticals, Inc.
- 当前专利权人地址： US PA Fort Washington
- 代理机构： McCarter & English, LLP
- 代理商 Steven G. Davis; Michael DeGrazia
- 优先权： WOPCT/US2008/009017 20080725
- 国际申请： PCT/US2009/002629 WO 20090430
- 国际公布： WO2009/134384 WO 20091105
- 主分类号： C07D417/14
- IPC分类号： C07D417/14 ; C07D413/14 ; A61K31/5355
摘要：
This invention relates to novel compounds of a structural formula selected from: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals, e.g., diabetes mellitus and obesity. Values for the variables in the structural formulas are provided herein. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
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