- 专利标题： Method and composition for crystallizing G protein-coupled receptors
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申请号： US12932101申请日： 2011-02-16
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公开(公告)号： US08178655B2公开(公告)日： 2012-05-15
- 发明人: Brian Kobilka , Daniel Rosenbaum
- 申请人： Brian Kobilka , Daniel Rosenbaum
- 申请人地址： US CA Palo Alto
- 专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址： US CA Palo Alto
- 代理机构： Bozicevic, Field & Francis LLP
- 代理商 James S. Keddie
- 主分类号： C07K14/705
- IPC分类号： C07K14/705 ; C07K19/00 ; C12N15/62
摘要：
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR.
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