A method and an apparatus for detecting a signal in a multi-antenna system using a spatial multiplexing are provided. The apparatus includes at least one antenna for receiving a signal, a channel estimator for estimating a channel using the received signal, a detector for calculating multiplication values commonly used to determine a Euclidean distance using the receive signal and channel information and for detecting a transmitted signal by calculating Euclidean distances of one or more candidate symbols using the receive signal and the determined multiplication values and a decoder for demodulating and decoding the detected signal. Hence, the computational complexity of the signal detection can be mitigated.