Invention Grant
US08101566B2 Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
有权
用于调节血管生成的人氨基-tRNA合成酶多肽
- Patent Title: Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
- Patent Title (中): 用于调节血管生成的人氨基-tRNA合成酶多肽
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Application No.: US12655717Application Date: 2010-01-06
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Publication No.: US08101566B2Publication Date: 2012-01-24
- Inventor: Paul Schimmel , Keisuke Wakasugi
- Applicant: Paul Schimmel , Keisuke Wakasugi
- Applicant Address: US CA La Jolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Olson & Cepuritis, Ltd.
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
A method of suppressing angiogenesis in a mammal (e.g., for treating tumors, tumor metastasis or a condition that would benefit from decreased angiogenesis) comprises the step of administering to the mammal an angiostatically effective amount of a pharmaceutical composition comprising an isolated antiangiogenic truncated tryptophanyl-tRNA synthetase (TrpRS) polypeptide or an isolated nucleic acid that comprises a polynucleotide sequence that encodes the truncated TrpRS polypeptide. The truncated TrpRS polypeptide comprises residues 71-471 of SEQ ID NO: 10, residues 48-471 of SEQ ID NO: 10, or a polypeptide of approximately 47 kD molecular weight produced by cleavage of the polypeptide of SEQ ID NO: 10 with polymorphonuclear leucocyte elastase.
Public/Granted literature
- US20100158883A1 Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis Public/Granted day:2010-06-24
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