发明授权
- 专利标题： Synthesis of scabronines and analogues thereof
- 专利标题（中）： scabronine及其类似物的合成
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申请号： US12017951申请日： 2008-01-22
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公开(公告)号： US07910623B2公开(公告)日： 2011-03-22
- 发明人: Samuel J. Danishefsky , Stephen P. Waters
- 申请人： Samuel J. Danishefsky , Stephen P. Waters
- 申请人地址： US NY New York
- 专利权人： Sloan-Kettering Institute for Cancer Research
- 当前专利权人： Sloan-Kettering Institute for Cancer Research
- 当前专利权人地址： US NY New York
- 代理机构： Choate, Hall & Stewart LLP
- 代理商 Brenda Herschbach Jarrell; Kristen C. Buteau
- 主分类号： A61K31/21
- IPC分类号： A61K31/21 ; C07C69/74
摘要：
A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.
公开/授权文献
- US20110009485A9 SYNTHESIS OF SCABRONINES AND ANALOGUES THEREOF 公开/授权日：2011-01-13
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