发明授权
- 专利标题: Mutant F. turlarensis strain and uses thereof
- 专利标题(中): 突变体F.格朗汉斯菌株及其用途
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申请号: US11918648申请日: 2006-04-19
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公开(公告)号: US07910351B2公开(公告)日: 2011-03-22
- 发明人: Anders Sjostedt , Joseph Wayne Conlan
- 申请人: Anders Sjostedt , Joseph Wayne Conlan
- 申请人地址: CA Ottawa
- 专利权人: National Research Council of Canada
- 当前专利权人: National Research Council of Canada
- 当前专利权人地址: CA Ottawa
- 代理商 Johanna Coutts
- 优先权: CA2502999 20050420
- 国际申请: PCT/CA2006/000621 WO 20060419
- 国际公布: WO2006/111019 WO 20061026
- 主分类号: C12N1/12
- IPC分类号: C12N1/12
摘要:
A mutant strain of Francisella tularensis has attenuated virulence and has a mutation in the gene coding for a putative peroxynitrite resistance protein A (prpA) which prevents normal function of the protein. The mutant is useful as a vaccine against type A and B virulent strains of F. tularensis, and is produced by obtaining a virulent F. tularensis strain and mutating the gene, FTT0918, that codes for prpA.
公开/授权文献
- US20090098163A1 Mutant F. turlarensis strain and uses thereof 公开/授权日:2009-04-16
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