发明授权
- 专利标题： Articles of manufacture and methods for modeling Saccharomyces cerevisiae metabolism
- 专利标题（中）： 酿造酵母代谢的制造和方法
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申请号： US10263901申请日： 2002-10-02
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公开(公告)号： US07751981B2公开(公告)日： 2010-07-06
- 发明人: Imandokht Famili , Jochen Förster , Pengcheng Fu , Jens B. Nielsen , Bernhard O. Palsson
- 申请人： Imandokht Famili , Jochen Förster , Pengcheng Fu , Jens B. Nielsen , Bernhard O. Palsson
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 代理机构： DLA Piper LLP (US)
- 主分类号： G01N33/48
- IPC分类号： G01N33/48 ; G06G7/48
摘要：
The invention provides an in silico model for determining a S. cerevisiae physiological function. The model includes a data structure relating a plurality of S. cerevisiae reactants to a plurality of S. cerevisiae reactions, a constraint set for the plurality of S. cerevisiae reactions, and commands for determining a distribution of flux through the reactions that is predictive of a S. cerevisiae physiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. The invention further provides methods for making an in silico S. cerevisiae model and methods for determining a S. cerevisiae physiological function using a model of the invention.
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